ESNano Technology Development Limited Successfully Target of Brain Tumor Cells in Mice.
Here at ESNano Technology Development Limited our research teams have spent the last 18 months performing a series of experiments in the proof of concept stage for our system. We have proposed a system, which can be used to identify cancerous cells and then used as a delivery system to treat diseased cells.
18 months ago, we started with a series of in vitro experiments. This is where the test procedures are carried out in a test tube or culture dish (these initial experiments are not carried out within a living system). After 6 months of experimenting our researchers found the initial results of the experiments and testing had produced promising and exciting results.
We were able to move onto the next phase of development, in vivo experiments, where ‘living tissue’ is experimented upon. We started in a set of simple tissue culture experiments before moving onto experiments with mice. This is a stage we had to carry out in vivo due to the complex nature of the way capillaries, which carry oxygenated blood into the brain form what is known as the Blood Brain Barrier (BBB). These capillaries unlike those found in other parts of the body only allow for the exchange of the smallest of molecules, such as the exchange of oxygen and carbon dioxide in the brain. The BBB has presented a significant obstacle in getting therapeutic agents into the brain tissue, as they are often too large to cross the BBB.
We attached imaging molecules to the gold nano-spheres we have developed. Our team of research scientists was then successfully able to show precisely where the tissues they were looking for are. We are now ready to move into the final phase of development by developing gold nano-sphere, which are capable of carrying the right amount of therapeutic agent to treat the tumor cells successfully and with the eradication of dangerous brain surgery usually associated with brain tumors. On the completion of these experiments, we will apply to carry out clinical trials.